Firing Rate Response to Altered CO2 in Chemosensitive
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Running Title: A Currents and the Chemosensitive Response of LC Neurons 19 20 21 Corresponding Author: Dr. Robert W. Putnam 22 Department of Neuroscience, Cell Biology and Physiology 23 Wright State University Boonshoft School of Medicine 24 3640 Colonel Glenn Highway 25 Dayton, OH 45435, USA 26 [email protected] 27 TEL: 01-937-775-2288 28 FAX: 01-937-775-3391 29 30 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (August 15, 2013). doi:10.1152/ajpregu.00029.2013
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Effect of temperature on chemosensitive locus coeruleus neurons of savannah monitor lizards, Varanus exanthematicus.
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Central chemoreceptors are highly sensitive neurons that respond to changes in pH and CO2 levels. An increase in CO2/H+ typically reflects a rise in the firing rate of these neurons, which stimulates an increase in ventilation. Here, we present an ionic current model that reproduces the basic electrophysiological activity of individual CO2/H+-sensitive neurons from the locus coeruleus (LC). We ...
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